Generation and Screening of Ditopic Dynamic Combinatorial Libraries

Dynamic Combinatorial Chemistry (DCC) is a new supramolecular concept that extends beyond static combinatorial chemistry towards adaptive chemical systems. This concept relies on reversible interchange between sets of basic components to generate continually interconnecting adducts, giving access to dynamic combinatorial libraries (DCLs) comprising all possible combinations of the components available. Such libraries allow for the target-driven generation of the active constituent(s) of the libraries, thus performing a selfscreening process by which the active species are preferentially expressed and retrieved from the DCL. In this study, the implementation of such libraries on biological interactions was examined and dynamic libraries, generated from small arrays of initial precursors, were probed against binding to biological receptors.